It's possible that the key was rebound to something else..
From the wikia page:
A wand or staff, but not a scepter, can be equipped with any of several wand foci. When the focus-equipped wand is right-clicked, it will activate the special ability ("spell") of the focus, using up vis. Wand Foci can be stored in a Focus Pouch, which keeps them all in one inventory slot, or even in the Baubles belt slot. To switch between the Wand Foci in your inventory, press 'F' (configurable) with your wand in hand, and you will see all your foci arranged in the middle of the screen, where you can move the cursor to pick a new one. 'Shift-F' will remove your current focus without putting another on.